| Chris Ray | Shoulder | Hoping to be ready for spring training |
| Brian Roberts | Back | Hoping to be ready for spring training |
| Adam Jones | Ankle | Expected to be ready for spring training |
| Álex Cora | Thumb | Expected to be ready for spring training |
| Mike Lowell | Thumb | Out until at least early March |
| Coco Crisp | Shoulder | Expected to be ready for spring training |
| Tim Wakefield | Back | Expected to be ready for spring training |
| Daisuke Matsuzaka | Back | Expected to be ready for spring training |
| Chien-Ming Wang | Shoulder | Out until at least early May |
| Dan Giese | Elbow | Hoping to be ready for spring training |
| Jesse Litsch | Forearm | 60-day DL. Out until at least early July |
| Dustin McGowan | Shoulder, knee | Out until at least early March |
| Octavio Dotel | Side | Out until at least early March |
| Danny Richar | Shoulder | Hoping to be ready for spring training |
| Gavin Floyd | Hip | Expected to be ready for spring training |
| Joe Crede | Back | Free agent. Hoping to be ready for spring training |
| Adam Miller | Finger | Out until at least mid-April |
| Jeremy Sowers | Shoulder | Out until at least early March |
| Cliff Lee | Foot | Out until at least early March |
| Grady Sizemore | Ankle | Might return March 2 |
| Brandon Inge | Knees | Out until at least mid-March |
| Bobby Seay | Shoulder | Out until at least early March |
| Vance Wilson | Back | Expected to be ready for spring training |
| Fernando Rodney | Shins | Out until at least early March |
| Édgar Rentería | Elbow | Expected to be ready for spring training |
| Jeremy Bonderman | Suspension | 3-game suspension |
| José Guillén | Hamstring, back, ankle | Expected to be ready for spring training |
| Pat Neshek | Elbow | Hoping to be ready for spring training |
| Jose Morales | Wrist | Out until at least mid-March |
| Nick Punto | Wrist | Expected to be ready for spring training |
| Boof Bonser | Shoulder | Expected to be ready for spring training |
| Erick Aybar | Wrist | Out until at least early March |
| Jeff Mathis | Finger | Expected to be ready for spring training |
| Kelvim Escobar | Shoulder | Out until at least late March |
| Dustin Moseley | Elbow, hip | Hoping to be ready for spring training |
| Scot Shields | Knee | Out until at least mid-March |
| Ryan Sweeney | Knees | Expected to be ready for spring training |
| Justin Duchscherer | Back | Out until at least early March |
| Dallas Braden | Foot | Out until at least early March |
| Lenny DiNardo | Foot | Expected to be ready for spring training |
| Joey Devine | Elbow | Out until at least late March |
| Jay Marshall | Shoulder | Out until at least mid-March |
| Eric Chávez | Back | Hoping to be ready for spring training |
| César Jiménez | Biceps | Hoping to be ready for spring training |
| Jarrod Washburn | Knee | Free agent. Hoping to be ready for spring training |
| Sean White | Shoulder | Hoping to be ready for spring training |
| J.J. Putz | Elbow | Expected to be ready for spring training |
| Rob Johnson | Hip, wrist | Out until at least mid-March |
| Cha Seung Baek | Elbow | Free agent. Might be out for the season |
| Adrián Béltre | Ankle | Expected to be ready for spring training |
| Erik Bedard | Shoulder | Out until at least late May |
| Ryan Feierabend | Elbow | Out until at least mid-March |
| Josh Hamilton | Shoulder | Out until at least early March |
| Ramón Vázquez | Knee | Hoping to be ready for spring training |
| Jarrod Saltalamacchia | Shoulder | Hoping to be ready for spring training |
| Matt Harrison | Shoulder, ribs | Hoping to be ready for spring training |
| Joaquín Benoit | Shoulder | Hoping to be ready for spring training |
| Jorge Campillo | Shoulder | Out until at least early May |
| Tyler Yates | Elbow | Out until at least late July |
| Jordan Schafer | Wrist | Expected to be ready for spring training |
| Jair Jurrjens | Shoulder | Out until at least mid-March |
| Mike Hampton | Shoulder, knees | Free agent. Out for the season |
| Justin Miller | Elbow | Hoping to be ready for spring training |
| Joe Nelson | Wrist | Hoping to be ready for spring training |
| Alfredo Amezaga | Knee | Hoping to be ready for spring training |
| Scott Olsen | Shoulder | Expected to be ready for spring training |
| Matt Treanor | Hip | Hoping to be ready for spring training |
| Collin Balester | Ribcage | Expected to be ready for spring training |
| Shawn Hill | Biceps | Out until at least late July |
| Jesús Flores | Shoulder | Out until at least mid-March |
| Ross Detwiler | Hip | Out until at least mid-May |
| Joel Hanrahan | Elbow | Out until at least early April |
| Joe Smith | Knee | Expected to be ready for spring training |
| Endy Chávez | Knee | Hoping to be ready for spring training |
| Carlos Delgado | Hip | Free agent. Out until at least late July |
| Johan Santana | Elbow | Out until at least mid-March |
| Carlos Beltrán | Knee | Out until at least late April |
| Carlos Carrasco | Quadriceps | Expected to be ready for spring training |
| J.C. Romero | Elbow | Expected to be ready for spring training |
| Jamie Moyer | Groin, knee | Out until at least mid-April |
| Brad Lidge | Knee | Out until at least late March |
| John Ennis | Elbow | Hoping to be ready for spring training |
| Mark DeRosa | Wrist | Out until at least early March |
| Ángel Guzmán | Triceps, knee | Hoping to be ready for spring training |
| Neal Cotts | Elbow | Out until at least late July |
| Ted Lilly | Shoulder, knee | Out until at least early April |
| Alfonso Soriano | Knee | Expected to be ready for spring training |
| Jose Ascanio | Shoulder | Out until at least mid-June |
| Edison Vólquez | Elbow | 60-day DL. Out until at least early August |
| Roy Oswalt | Back | Expected to be ready for spring training |
| Oscar Villarreal | Elbow | Out until at least mid-April |
| David Riske | Elbow | Out until at least early June |
| Manny Parra | Shoulder | Hoping to be ready for spring training |
| Rickie Weeks | Wrist | Expected to be ready for spring training |
| Xavier Nady | Elbow | Hoping to be ready for spring training |
| Evan Meek | Oblique | Expected to be ready for spring training |
| Freddy Sánchez | Shoulder, knee | Out until at least early April |
| Brendan Ryan | Wrist | Out until at least mid-March |
| Anthony Reyes | Elbow | 60-day DL. Out until at least late July |
| Albert Pujols | Elbow | Expected to be ready for spring training |
| Chris Snyder | Back | Hoping to be ready for spring training |
| Conor Jackson | Illness | Hoping to be ready for spring training |
| Chris Burke | Finger | Out until at least mid-March |
| Chad Qualls | Knee | Expected to be ready for spring training |
| Brandon Lyon | Shoulder | Out until at least early March |
| Donnie Sadler | Shoulder | Hoping to be ready for spring training |
| Greg Reynolds | Shoulder | Might be out for the season |
| Alberto Arias | Knee | Hoping to be ready for spring training |
| Taylor Buchholz | Elbow | Out until at least mid-June |
| Jeff Francis | Shoulder | Out until at least early March |
| Brad Hawpe | Toe | Expected to be ready for spring training |
| Manny Corpas | Elbow, hamstring | Out until at least early March |
| Scott Proctor | Elbow | Out until at least mid-June |
| Khalil Greene | Anxiety | Out until at least early March |
| Michael Barrett | Shoulder | Hoping to be ready for spring training |
| Noah Lowry | Shoulder, elbow | Free agent. Hoping to be ready for spring training |
